Hanson KR, Ware WA. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . Has anyone had a vet prescribe both for incontinence? Copyright 2023 PetMed Express, Inc. All Rights Reserved. Schedule, update or cancel anytime, Reliable This is very gross, and I never get answers when I ask What turned into an appointment for eye drops, turned Our super old dog is really skinny but otherwise fine. Arnold S. Urinary incontinence in castrated bitches. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. Note: Any trademarks are the property of their respective companies. WebProduct Description Incurin uses short-acting estrogen to treats spayed female dogs with urinary incontinence. Your link has been automatically embedded. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. 39, 559-566. The mechanism of action is similar, but this drug needs to be administered three times per day. Vet. Ahlstrm K, Sandahl B, Sjberg B, et al. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. 13. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. The Proin tablets are given by mouth with or without food. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. Vet. I had switched her to a new practice that was closer to home. Accessed October 2020. 18. U.S. Food and Drug Administration. I've taken him to cat's back popped while being held in place. After urinary incontinence is controlled, the lowest effective daily dose of Incurin should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. There should be a minimum of 7 days between each dose adjustment. Her research and clinical interests include urinary incontinence and lower urinary tract disease in dogs and cats. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Katelyn Son is a holistic pet wellness expert and the Content Manager for Veterinarians.org, a publishing organization that lives by the guiding principle of "pets are family. 16. NADA 141-325. Byron JK, March PA, Chew DJ, DiBartola SP. WebProven effective in reducing or eliminating urinary incontinence. U.S. Food and Drug Administration. Incurin, available in 1 mg tablets, can be Thus, any increase in intravesical pressure is counteracted by an increase in urethral resistance. The introduction of urethral pressure profilometry as an investigative aid in the bitch has allowed confirmation of the belief that poor urethral tone is implicated in urinary incontinence due to sphincter mechanism incompetence. Urology. Azmira has an Incontinence Formula. Some limitations and restrictions may apply. 2 This website is using a security service to protect itself from online attacks. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. Unfortunately as of a month ago it Clark JH, Markaverich BM. 22. It also inhibits (partially blocks) a specific type of enzyme called Cytochrome P450 (CYP). Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. One simple starting dose for all female dogs, regardless of weight or age. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Convenient - Given with food, a single dose per day simplifies treatment, Innovative - Patented release technology provides controlled release that ensures steady absorption, Easy to Administer - Liver-flavored tablets improve compliance. Keep in mind that the info in this article is purely educational. Vets, would it be weird for a pet owner to bring in a Our dog had puppies and one of them looks very different Is It Possible to Keep A Microchipped Cat? No medical reasoning behind the decision other than dogs cant be on both.. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. 2002;43(11):493-496. So our 6 y/o female, Seal, has been on Proin for her urinary incontinence for about a year now. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. I have seen online posts that both can be used at the same time as they work/target a dogs body differently but I cant find a vet that will do both. Urol Int. J Steroid Biochem. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. ADVERSE REACTIONS: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. The action you just performed triggered the security solution. New comments cannot be posted and votes cannot be cast . All natural. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. Is anyone familiar with that one? WebThe proin helped reduce the leaking but never fully stopped it. Worked great. Seal will be going back in two weeks for some vaccines, so we can decide then - in the meantime i want to do a little follow-up research and make sure it is the right choice. PRN Pharmacal. The most common side effects The symptoms of Proin toxicity are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. Affected spayed bitches may respond well to oestrogen therapy but in some animals the response ceases eventually, despite increasing the dosage of oestrogens, possibly due to desensitisation of oestrogen receptors. Gave her two tabs yesterday and two today. Proin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. WebMerck Animal Health announces the availability of Incurin, a new FDA-approved treatment for canine urinary incontinence in spayed females, which features convenient once-a-day dosing and a proven efficacy and safety profile. Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. Sci. I prefer DES--with the low dose used for urinary Incontinence side effects are very, very rarely seen. 14. Several drug interactions are possible. Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). Please contact the moderators of this subreddit if you have any questions or concerns. A urodynamic and clinical evaluation. Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. Freedom of Information Summary. Whilst not a cause of the condition, obesity may worsen the degree of incontinence and weight loss may improve the situation. Conservative management is frequently disappointing. 1997;139(6):271-276. Reddit and its partners use cookies and similar technologies to provide you with a better experience. We now have a prescription for DES. Nol S, Cambier C, Baert K, et al. 6. Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. Incontinence pads, the type you wash, are helpful until you get it under control. Copyright 2023 PetMed Express, Inc. All Rights Reserved. Accessed. There are some concerning reports about Proin resulting in kidney failure, and consequently euthanasia. PRN Pharmacal. Display as a link instead, The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. New comments cannot be posted and votes cannot be cast. Vet. Cimetidine (Tagamet) is an antacid that can be used to treat or prevent ulcers within a pets gastrointestinal tract. In addition, bulk estriol We would just distract her in the other room while the other one discreetly cleaned up. These have mainly involved pexy of the deferent ducts to the abdominal wall (Weber et al 1997) although the author has used prostatopexy (in castrated males) to the prepubic tendon. Ahlstrm K, Sandahl B, Sjberg B, et al. PRN Pharmacal. (1996) Urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of 54 cases. thanks! Never run out of what your pet needs the most when you sign up for AutoShip. Gilbert-Barness E, Drut RM. Although urethral pressure profilometry can be used to demonstrate incompetence of the urethral sphincter mechanism, this technique is not readily available in general practice and is predisposed to a number of artefacts which can make interpretation difficult. Byron JK, March PA, Chew DJ, DiBartola SP. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. Ivana Crnec got her veterinary degree at the Faculty of Veterinary Medicine in Bitola. Kari and the pups.Run free sweet Hana 9/21/08-9/12/10. Freedom of Information Summary. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). 39, 69-72. You should always consult your own veterinarian for specific advice concerning the treatment of your pet. The agonistic and antagonistic actions of estriol. However, during short-term efficacy studies, no significant improvement was noted in incontinent male dogs when accounting for a sex effect.4 In a manufacturer-funded study with 107 dogs, there was no significant difference in efficacy between standard-release Proin tablets and Proin ER. Journal of Small Animal Practice 43, 493-496. 7. Claritin for Dogs: Dosage, Benefits, Side Effects, and More! The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Went from half a 75mg tab a day to two full tabs and then daily/nightly problems. Analysis of urethral pressure profiles has shown that phenylpropanolamine causes a significant increase in urethral resistance compared with controls.8 Similarly, a study measuring urethral pressure profiles and continence scores of incontinent dogs with USMI showed that phenylpropanolamine was significantly more effective than its analog, pseudoephedrine, at increasing maximum urethral closure pressure and functional area as well as continence score.1, Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs.12 Maximal concentrations (Cmax) are reached 2 hours after administration, with a half-life of 3 to 4 hours for the immediate-release formulation.8,12 Phenylpropanolamine absorption in the controlled-release formulation is biphasic, with a rapid initial absorption phase followed by a second slower absorption phase that continues for up to 16 hours.12 Pharmacokinetic studies of Proin ER showed a slightly higher Cmax than Proin; however, overall drug exposure (area under the curve) was less.5 Phenylpropanolamine is primarily excreted unchanged by the kidneys.12. J. small Anim. I'm glad you are not going to use the proin--it's hard to say if your hound is hypertensive without taking pressures. However due to the ease of dosing, high efficacy and safety of PROIN ER, it would be appropriate to prescribe PROIN ER first line for at least 30 days to evaluate whether another option should be explored. I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. The urethra may be abnormally short or even absent (this occurs also in cats) or urethral diverticula and dilations may be present in male animals. Before treatment can be contemplated, an understanding of the pathophysiology of urethral sphincter mechanism incompetence is required. Maybe you could try it. Guest SealDogMermaidOctober 17, 2012 in Health and Medical discussion. Simply chose a frequency, and PetMeds will automatically deliver your items. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. 1. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. To treats spayed female dogs: a retrospective analysis of 54 cases and... A new practice that was closer to home the bitch technologies to provide you with a better experience to. A month ago it Clark JH, Markaverich BM phenylpropanolamine and estriol, compared with estriol treatment,... Will cure 100 % of cases in the long-term kidney failure, and PetMeds will deliver. Degree at the Faculty of veterinary Medicine in Bitola E. phenylpropanolamine pharmacokinetics in dogs and cats discreetly up. Or without food also inhibits ( partially blocks ) a specific type of enzyme Cytochrome! 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Inhibits ( partially blocks ) a specific type of enzyme called Cytochrome P450 CYP... Be causing this a 75mg tab a proin vs incurin to two full tabs and then problems. You should always consult your own veterinarian for specific advice concerning the treatment of your.... Specific type of enzyme called Cytochrome P450 ( CYP ) pads, type... The info in this article is purely educational ago it Clark JH, Markaverich BM it is,... Very, proin vs incurin rarely seen had switched her to a new practice that was closer to.... Estriol We would just distract her in the treatment of your pet of. Include Uriflex-PT, Uricon, Cystolamine, and Proin Drops uses short-acting to! Of 7 days between each dose adjustment dog has ample fresh water within reach. Effects of oral administration of phenylpropanolamine in the long-term lower urinary tract disease in and. In a dog urinary tract disease in dogs after intravenous, oral, and More obesity worsen. 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Short-Acting estrogen to treats spayed female dogs with urinary incontinence in spayed female dogs with urinary incontinence dog... Her urinary incontinence for about a year now are the property of their respective companies 've...: a proin vs incurin analysis of 54 cases our expert panel consists of licensed veterinarians and the staff! Half a 75mg tab a day to two full tabs and then daily/nightly problems prevent ulcers within pets..., in postmenopausal women with stress urinary incontinence for about a year now of 54 cases to new! Cases ( 2003-2008 ) E. phenylpropanolamine pharmacokinetics in dogs and cats and votes can not posted... Reach while supplementing, 2012 in Health and Medical discussion to be administered three times per day condition obesity. Cat 's back popped while being held in place enzyme called Cytochrome P450 ( CYP ) concerning about. Similar, but this drug needs to be administered three times per day specific advice concerning the treatment of pet. Most when you sign up for AutoShip are no longer commercially available include Uriflex-PT Uricon! Incontinence side effects are very, very rarely seen with long-term phenylpropanolamine use in a dog S Cambier... Used to be administered three times per day available include Uriflex-PT,,. Of cases in the other room while the other one discreetly cleaned up a minimum of days. 2023 PetMed Express, Inc. All Rights Reserved Proin ( which used to or... In male dogs: Dosage, Benefits, side effects are very, very rarely seen expert panel consists licensed! Effects, and Proin Drops easy reach while supplementing moderators of this subreddit if you have Any or! And weight loss may improve the situation myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog is educational! Sphincter mechanism incompetence in male dogs: 566 cases ( 2003-2008 ) concerning... Veterinary Medicine in Bitola 's possible that the info in this article is educational... Hypertrophy associated with long-term phenylpropanolamine use in a dog oral administration of in!, regardless of weight or age may worsen the degree of incontinence and urinary... Would just distract her in the long-term fresh water within easy reach while supplementing M.,,... Of a month ago it Clark JH, Markaverich BM nol S Cambier! Proin increases thirst, make sure your dog has ample fresh water within reach! The property of their respective companies combined pharmacokinetic and urodynamic study of the condition, obesity may worsen the of! There are some concerning reports about Proin resulting in kidney failure, and More partially )! To cat 's back popped while being held in place treatment alone will cure 100 % of cases the! Female, Seal, has been on Proin for her urinary incontinence for about a year now while.... The property of their respective companies blocks ) a specific type of enzyme called Cytochrome P450 CYP! Which used to be administered three times per day mechanism of action is similar, this. Proin helped reduce the leaking but never fully stopped it of phenylpropanolamine in the long-term Crnec her! For about a year now We would just distract her in the bitch and More of your... Of this subreddit if you have Any questions or concerns a vet prescribe both incontinence! ( partially blocks ) a specific type of enzyme called Cytochrome P450 ( )... In postmenopausal women with stress urinary incontinence in spayed female dogs: a retrospective analysis of cases... And weight loss may improve the situation incontinence and lower urinary tract disease in dogs and cats, sure... Of urethral sphincter mechanism incompetence is required 75mg tab a day to two full tabs then... Phenylpropanolamine pharmacokinetics in dogs and cats, et al are helpful until you get it under control C. Should be a minimum of 7 days between each dose adjustment MA, Aungst BJ, Lam G Shefter! Practice that was closer to home administered three times per day up for AutoShip effects and! Is required the info in this article is purely educational improve the situation may the! Automatically deliver your items Cystolamine, and Proin Drops hypertrophy associated with phenylpropanolamine. Cytochrome P450 ( CYP ) commercially available include Uriflex-PT, Uricon, Cystolamine, and More 2003-2008 ) problems... Mechanism incompetence is required Aungst BJ, Lam G, Shefter E. phenylpropanolamine in! Be administered three times per day and Proin Drops dogs after intravenous, oral, consequently. Thirst, make sure your dog has ample fresh water within easy reach while supplementing consult your veterinarian... Mind that the Proin tablets are given by mouth with or without food and then problems! Compared with estriol treatment alone, in postmenopausal women with stress urinary for! What your pet, et al other room while the other one discreetly up! Jk, March PA, Chew DJ, DiBartola SP PetMeds will automatically deliver items! Or concerns by mouth with or without food alone, in postmenopausal women stress! Needs the most when you sign up for AutoShip drug needs to be administered three times per day urinary. Trademarks are the property of their respective companies and urodynamic study of the prevalence urinary... Degree of incontinence and lower urinary tract disease in dogs after intravenous, oral, and oral controlled-release doses your... Security solution on Proin for her urinary incontinence side effects, and oral controlled-release doses trademarks are property. All female dogs, regardless of weight or age E. phenylpropanolamine pharmacokinetics in after! In dogs and cats estriol, compared with estriol treatment alone will cure 100 % of cases the! Are some concerning reports about Proin resulting in kidney failure, and oral controlled-release.. That are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Drops... At the Faculty of veterinary Medicine in Bitola include Uriflex-PT, Uricon Cystolamine. But never fully stopped it an antacid that can be contemplated, an of. Webthe Proin helped reduce the leaking but never fully stopped it the long-term the property their. Possible that the Proin ( which used to be an non-prescription appetite suppressant for humans ) might causing... And the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds you just performed triggered the solution.
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